Figure 3.

Dirichlet multinomial mixture models support the presence of 2 OTU types and 2 metabotypes. (A and B) The model fit is shown for the given number of (A) OTU types and (B) metabotypes estimated from Dirichlet multinomial mixture models using the Laplace approximation. The exponent of the difference in model fit is the estimated probability of one model over another. (C) No statistically significant difference in Bacteroides or Prevotella abundance was observed between the 2 OTU types in our cohort. Ruminococcus was increased in OTU type 1 but this was not the exclusive driver of OTU type because 2 individuals with OTU type 2 had greater Ruminococcus levels than all individuals with OTU type 1. **P < .005.