Figure 9.

Healthy first-degree relatives with the IBD-associated microbial community type are at higher risk for increased fecal calprotectin. (A) Unadjusted odds ratios (ORs) and 95% confidence intervals were calculated for IBD risk using univariate logistic regression. Adjusted ORs were obtained from a multivariate logistic regression model incorporating OTU type, metabotype, parent/child status, and Jewish ethnicity. (B) Dot plot showing fecal calprotectin in the 54 healthy first-degree relatives, stratified by OTU type. The lowest 2 rows of dots represent samples below or near the limit of detection of 15.6 μg/g. The P value was calculated from univariate logistic regression for increased calprotectin level (cut-off value is indicated by the dashed line). (C) Pedigrees are shown for 5 families with healthy children who carry an IBD-associated OTU type. Two of these children had an increased fecal calprotectin level.