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(A) Western blot analysis of Gαq/Gα11 expression in 4 mouse lines: control (Gnaqflox/floxGna11+/+), Int-Gq KO (VilCre+/-Gnaqflox/floxGna11+/+), G11 KO (Gnaqflox/floxGna11-/-), and Int-Gq/G11 DKO (VilCre+/-Gnaqflox/floxGna11-/-). (B) H&E staining in small intestine of Int-Gq/G11 DKO mice. Enlarged Paneth cells were distributed along the crypt–villus axis. (C) HE staining in large intestine of 4 mouse lines. Morphologic changes were not detected. Scale bars: 200 μm.
