Table 3.

Adjusted Association of Adhesion Proteins with ABI and with ABI Category.

	Ankle-brachial index (ABI)				ABI ≤ 1.00 vs ABI > 1.00
Adhesion protein	Model 1a Betac (SE)	P Value	Model 2b Betac (SE)	P Value	Model 1a OR (95% CI)	P Value	Model 2b OR (95% CI)	P Value
CCL-21	−0.003 (0.003)	.30	−0.0004 (0.003)	.86	1.10 (0.96-1.26)	.19	1.04 (0.89-1.21)	.61
E-cadherin	−0.006 (0.002)	.007	−0.004 (0.003)	.12	1.20 (1.06-1.37)	.004	1.13 (0.97-1.30)	.12
HGF	−0.005 (0.002)	.05	−0.009 (0.003)	.001	1.19 (1.04-1.37)	.01	1.20 (1.04-1.39)	.01
ICAM-1	−0.003 (0.002)	.15	−0.004 (0.002)	.13	1.03 (0.93-1.21)	.37	1.05 (0.91-1.20)	.54
IL-2sr	−0.007 (0.002)	.005	−0.005 (0.003)	.04	1.20 (1.06-1.35)	.003	1.15 (1.01-1.30)	.04
L-selectin	0.005 (0.002)	.03	0.003 (0.002)	.19	0.95 (0.82-1.10)	.46	0.72 (0.54-0.97)	.03
MMP-1	−0.004 (0.002)	.05	−0.005 (0.002)	.05	1.08 (0.95-1.22)	.24	1.08 (0.94-1.23)	.28
MMP-2	−0.001 (0.002)	.69	0.0001 (0.002)	.94	0.94 (0.82-1.09)	.43	0.91 (0.79-1.06)	.21
P-selectin	−0.010 (0.002)	< .0001	−0.008 (0.002)	.0004	1.28 (1.11-1.46)	.0004	1.26 (1.10-1.46)	.001
RANTES	−0.005 (0.002)	.02	−0.005 (0.002)	.02	1.13 (1.01-1.27)	.04	1.14 (1.01-1.28)	.03
SDF-1b	0.0008 (0.002)	.74	0.0007 (0.002)	.75	0.97 (0.85-1.11)	.65	0.95 (0.82-1.09)	.46
SLPI	−0.011 (0.002)	< .0001	−0.008 (0.003)	.002	1.26 (1.10-1.43)	.0006	1.19 (1.03-1.37)	.02
TGF-β1	−0.005 (0.002)	.05	−0.005 (0.002)	.02	1.10 (0.97-1.25)	.12	1.12 (0.98-1.28)	.09
TIMP-2	0.003 (0.002)	.18	0.003 (0.003)	.15	0.93 (0.80-1.07)	.30	0.90 (0.77-1.05)	.19
VCAM-1	−0.002 (0.002)	.31	−0.0005 (0.002)	.83	1.07 (0.93-1.24)	.32	1.02 (0.88-1.18)	.82

Abbreviations as in Table 2.

^aMinimally adjusted model including age, sex, race/ethnicity and field site.

^bFully adjusted model including Model 1+ BMI, ever smoking, diabetes, hypertension, estimated Glomerular Filtration Rate (eGFR), triglycerides, LDL, HDL and total cholesterol.

^cBeta coefficients represent the difference in ABI for each SD increase in adhesion proteins.