Table 3.

Summary of Differences Between NTM and GTM Cells

	Feature	Difference in GTM
TM Tissue (in vivo)	TM cellularity	Decrease
	Deposition of ECM in outflow pathway	Increase
	Fibronectin expression	Increase total Increase EDA isoform
	Elasticity	Decrease at JCT Increase circumferentially
	TGFβ2 expression	Increase
	TGM2 expression	Increase
	sCD44 expression	Increase
	ELAM1 expression	Increase
	Cochlin expression	Increase
	ER/protein misfolding stress	Increase
TM Cells (in vitro)	Migratory ability	Decrease
	Autophagy	Decrease
	GC responsiveness	Increase
	GRβ expression	Decrease
	CLANs	Increase
	TGFβ2 expression	Increase
	Gremlin expression	Increase
	SFRP1 expression	Increase
	Cochlin expression	Increase
	SAA2 expression	Increase

[See Sections VI and VII for details and references]