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. 2016 Oct 21;3(1):51–71. doi: 10.1016/j.jcmgh.2016.10.001

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SPDEF functions as a transcriptional co-regulator of ATOH1. (A) Flow chart for identifying SPDEF binding motifs within ATOH1 binding regions in the colon ATOH1 targetome. P values are for motif enrichment. (B) Real-time PCR analysis of complementary DNAs synthesized from mRNA isolated from mouse colonic crypts. Spdef null or littermate wild-type control mice were treated with either vehicle or dibenzazepine (DBZ) for 5 consecutive days. Relative fold change is presented as means ± SEM (*P < .05 and ***P < .001). ANOVA, analysis of variance; TFs, transcription factors.