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. 2017 Jan 20;8:3. doi: 10.3389/fphys.2017.00003

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Copyright © 2017 Shiozaki, Sato, Kimura, Sato, Tazaki and Shibukawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inward currents evoked by K⁺-ATP and BzATP, but not by αβ-MeATP. (A–D) Example traces of inward current evoked by 100 μM K⁺-ATP (A) or 300 μM BzATP (C). Application of 100 μM αβ-MeATP did not induce any currents (B). BzATP (300 μM) induced current was suppressed by 20 nM KN62 (D). These currents were recorded at Vh = −70 mV. (E) Bar graph shows a summary of the peak current densities elicited by application of each K⁺-ATP, BzATP, αβ-MeATP, as well as BzATP with KN62. Each bar indicates the mean ± SD of three separate experiments. Statistically significant differences between bars (shown by solid lines) are indicated by asterisks, ^*P < 0.05. (F) Dose-response relationship of absolute values of current density induced by BzATP in various concentrations. Each data point represents the mean ± SD from three cells. The curve (solid line) on a semilogarithmic scale was fitted to Equation (2). Applied concentration of BzATP is shown by x.