Table 2.

Urinary F_4-neuroprostanes, F₃-neuroprostanes, and F₂-dihomo-isoprostanes (ng mg⁻¹ creatinine) determined in the five study groups of the most representative life-stages in humans.

			Childhood		Adolescence		Young adults		Middle-aged		Elderly		Kruskal-Wallis
			(4- 12 year)		(13–17 years)		(18–35 years)		(36–64 years)		(≥65 years)
		ng/mg creatinine	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	χ2	Sig
From		Number in age groups (W/M)	20 (9/11)		14 (7/7)		45 (23/22)		58 (31/27)		21 (10/11)
A)		17-epi−17F2t -dihomo-IsoP	2.14	0.18	1.63	0.22	1.68	0.12	1.74	0.11	1.93	0.18	8.37(4)		0.079
	AdA	17-F2t-dihomo-IsoP	1.74	0.14	1.34	0.17	1.41	0.09	1.53	0.08	1.71	0.15	14.67(4)		0.005
	n−6
		ent−7-(R)−7-F2t-dihomo-IsoP	4.45	0.28	3.05	0.34	3.48	0.19	4.56	0.17	5.26	0.28	21.85(4)		≤0.001
		ent−7-epi−7-F2t-dihomo-IsoP	3.49	0.44	1.98	0.53	2.51	0.30	3.08	0.27	3.29	0.46	29.86(4)		≤0.001
			Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
B)	DHA	4-(R)-F4t-NeuroP	n/d	–	n/d	–	n/d	–	n/d	–	n/d	–			–
	n−3
		10- epi−10-F4t-NeuroP	n/d	–	n/d	–	n/d	–	n/d	–	n/d	–			–
		10-F4t-NeuroP	n/d	–	n/d	–	n/d	–	n/d	–	n/d	–			–
		4-F4t-NeuroP	n/d	–	n/d	–	n/d	–	n/d	–	n/d	–			–
	DPA n−6	4-epi−4F3t-NeuroP	n/d	–	n/d	–	n/d	–	n/d	–	n/d	–			–
		4-F3t-NeuroP	n/d	–	n/d	–	0.87a	0.57	10.48b	0.85	2.15c	1.17			–

A) Dihomo-Isoprostane. Data presented as mean±SEM (Standard error of the mean) ng mg⁻¹ creatinine. Kruskal-Wallis test, χ2: Chi-square (degree of freedom), and P<0.05 was significant. Abbreviations: W: women and M: men.

B) Neuroprostane. Data presented as means±SD (standard deviation) ng mg⁻¹ creatinine. Abbreviations: n/d: not detected. No data on neuroprostanes were found with the only exception of 4-F_3t-NeuroP, which was found in a reduced number of volunteers within the experimental groups: young adults (a, detected in 3 women and 7 men), middle age adults (b, detected in 9 women and 6 men), and in elder volunteers (c, detected in 2 women and 6 men).