Figure 1.

A schematic of our biologically tuned STDP model with pre- and postsynaptic expression. (a) The synaptic weight is the product of the release probability Pr and the quantal amplitude q. Changes in these parameters owing to STDP are modelled as functions of presynaptic activity trace x₊ and postsynaptic activity traces y₊ and y₋. (b) The fitted model captures the estimated changes in release probability (left) and quantal amplitude (right) for both positive timing (presynaptic spikes 10 ms before postsynaptic ones; blue) and negative timing (presynaptic spikes 10 ms after postsynaptic ones; red), as a function of the frequency of STDP pairings. Symbols indicate data, whereas lines denote the model fit. (c) After LTP, the release probability is enhanced, which leads to stronger short-term depression. The change in short-term synaptic dynamics in the model (bottom) mimics the data (top). Panels (b) and (c) are reproduced with permission from [16].