Table 2a.
The dynamics of the selected cytokines appearance in sera of infected mice.
| Cytokines (pg/ml) | Day of infection | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | ||||||||
| Abset | EK | Abset | EK | Abset | EK | Abset | EK | Abset | EK | Abset | EK | Abset | EK | |
| TNF-α | – | – | – | – | – | – | – | – | – | 107 | – | – | 315 ± 43 | n/a |
| IL-10 | 101 ± 34 | – | 9 ± 7 | – | 14 ± 7 | – | – | – | – | – | – | – | 45 ± 14* | 33 ± 1* |
| IFN-γ | – | – | – | – | – | 30 ± 2 | 27 ± 5 | 49 ± 11 | 39 ± 10 | – | – | – | 284 ± 36 | n/a |
| IL-12 | – | – | 328 ± 17 | – | – | – | – | 292 ± 31 | n/a | n/a | n/a | n/a | n/a | n/a |
| IL-6 | – | – | – | – | – | 74 ± 6 | 69 ± 9 | – | – | – | – | – | 640 ± 85 | 113 ± 9 |
| IL-2 | – | – | – | – | – | – | – | – | – | – | – | – | – | n/a |
Animals were IP infected with 103 PFU of the brain grown stocks of the Absettarov and EK-328 strains.
n/a–not analyzed.
“–”– concentration of cytokine lower than in control serum, which was obtained from animals after injection of brain suspension from non-infected animals with subsequent dilution (pg/ml): TNF-α, 23 ± 5; IL-10, 5 ± 2; IFN-γ, 25 ± 2; IL-12, 131 ± 56; IL-6, 16 ± 1; IL-2, 10 ± 2.
*
Indicates the data for sick animals; for mice without clinical manifestation, the concentration of the interleukin on the indicated day was lower than in the control.