FIGURE 8.
Heating to 42 °C inhibits Gd3+-potentiated mouse TRPC5 and mouse TRPC5R593A currents. A, B, D, and E, sample traces of histamine and GTPγS-induced TRPC5 and TRPC5R593A currents. Gd3+ (100 μm) and the extracellular solution heated to 42 °C was added at the times indicated by the horizontal bars. The broken black lines indicate the level of the zero current. C and F, summary data for current inhibition by the extracellular solution heated to 42 °C (Vholding = −100 mV, the vertical error bars represent standard deviation, and the mean values are indicated with horizontal bars; ns stands for not significant, Mann-Whitney Rank Sum Test).