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. 2017 Jan 20;7:40980. doi: 10.1038/srep40980

Figure 2. LanCL protein expression in different LanCL KO mouse lines.

Figure 2

(a) Genomic sequences indicating the mutations in Lancl1−/− (#36), Lancl2−/− (#52) and Lancl3−/− (#67) mice. Red letters indicate ZFN cutting site. Deleted nucleotides in mutant mice are shown as dashes. (b–e) Western blotting confirmed the complete KO of LanCL proteins in the corresponding LanCL KO mouse lines. (b) Lancl1−/−, (c) Lancl2−/−, (d) Lancl3−/− and (e) TKO mice were sacrificed with age- and gender-matched WT mice. Protein was extracted from brains and subjected to Western blotting with loading control.