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. 2017 Jan 20;7:40980. doi: 10.1038/srep40980

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MRM chromatogram for the transition of (a) 190.1 → 144.1 Da for LK, and (b) 194.1 → 148.0 Da for isotopically labeled LK in WT mouse brain. Also shown are the corresponding transitions (c) 190.1 → 144.1 Da and (d) 194.1 → 148.0 Da in LanCL1 KO mouse brain. The elution time for each peak is shown.