Figure 2. Schematic illustration of dual-targeted uptake of hydrogels and intracellular drug release.

Hydrogels in circulation accumulate in the target tissue by the combination of EPR effect of the leaky vasculature and strong local magnetic field applied by the external magnet. Then, uptake of FA-conjugated hydrogels into cells is mediated by the folate receptor via receptor-mediated endocytosis. Image courtesy by Ara Jo.