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. 2017 Jan 20;7:41099. doi: 10.1038/srep41099

Figure 9. HIF-1α inhibition lead to miR-127-3p expression decrease and Bcl6 expression enhance.

Figure 9

Expression of miR-127-3p and its target gene Bcl6 was estimated by qRT-PCR in renal tissue from I/R rats (n = 5 in each experimental group). Data are expressed as fold change using RNU6B and 5S mean and 28S levels as references in miR-127-3p and Bcl6 respectively. Asterisks indicate statistical significance (*P < 0.05, +/− s.d.). HIF-1α interference leads to miR-127-3p expression decrease during ischemia and at 3–5 days of reperfusion as compared to scrambled control. Consequently, we found an upregulation of miR-127-3p target gene Bcl6 at the same times. Experimental chirurgic model, RNA extraction and qRT-PCR were performed during 2011.