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. 2017 Jan 20;7:40878. doi: 10.1038/srep40878

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) TLR5 signaling activities of bsflagellin^cent, sdflagellin^cent, paflagellin^cent, sfflagellin^cent, and ecflagellin^cent, compared to WT flagellins. Activities were determined using the HEK293^TLR5 reporter cell assay. (b) Schematic representations of the flagellin deletion constructs (Del1, Del2, Del3, Del4, and cent). The N- and C-termini of flagellin are labeled as ‘N’ and ‘C’, respectively. (c) TLR5 signaling activities of bsflagellin-Del1, Del2, Del3, Del4, and cent, compared to bsflagellin^WT. Activities were determined using the HEK293^TLR5 reporter cell assay. (d) TLR5 signaling activities of sdflagellin-Del1, Del2, Del3, Del4, and cent, compared to WT sdflagellin.