Table 2. Summary of the gene-set enrichment analysis of porcine blood cDC transcriptomes versus orthologous human and mouse cDC subsets.
| Porcine blood cell type Gene sets | Pairwise comparisons between mouse or human cell types | Enriched in | Enrichment Score (ES)a | P - valueb | False Discovery Rate (q)b |
|---|---|---|---|---|---|
| CD1− vs CD14+ up | Human cDC1 vs CD14+ cMo | cDC1 | 0.46 | 0 | 0.002 |
| CD1− vs CD14+ up | Mouse cDC1 vs Ly6c+ cMo | cDC1 | 0.50 | 0.171 | 0.299 |
| CD1− vs CD14+ down | Human cDC1 vs CD14+ cMo | cMoc | −0.67 | 0.005 | 0.007 |
| CD1− vs CD14+ down | Mouse cDC1 vs Ly6c+ cMo | cMo | −0.59 | 0.113 | 0.266 |
| CD1+ vs CD14+ up | Human cDC2 vs CD14+ cMo | cDC2 | 0.49 | 0.003 | 0.005 |
| CD1+ vs CD14+ up | Mouse cDC2 vs Ly6c+ cMo | cDC2 | 0.53 | 0.021 | 0.013 |
| CD1+ vs CD14+ down | Human cDC2 vs CD14+ cMo | cMo | −0.64 | 0 | 0.002 |
| CD1+ vs CD14+ down | Mouse cDC2 vs Ly6c+ cMo | cMo | −0.55 | 0.025 | 0.057 |
aThe ES is calculated out of a possible maximum of 1 and minimum of −1.
bValues of p ≤ 0.1 and q ≤ 0.25 are considered to indicate significant enrichment.
cClassical monocytes.