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. 2017 Jan 20;7:41224. doi: 10.1038/srep41224

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Inhibition of NUCKS Resulted in Reduced Expression of Antiangiogenic and Angiogenic Cytokines, (A) PEDF and (B) VEGF. Following injury corneas were harvested from NWT and NKO mice at particular time points. Compared with NWT mice, the relative expression level of PEDF (~2.63-fold, **P < 0.001) was upregulated in NKO mice on day 7 and returned to normal on day 14. Furthermore, the relative expression level of VEGF was downregulated (~1.86-fold, **P < 0.001) in NKO mice on day 14 (NWT, N = 12; NKO, N = 12).