Figure 7. The PKA pathway was not involved in the anti-apoptotic action of nesfatin-1 in MES23.5 cells.
(A,B) Pretreatment with KT5720 (1 μmol/L) did not block the protective effect of nesfatin-1 (10−9 mol/L) on the collapse of the ΔΨm induced by MPP+. (C,D) Pretreatment with KT5720 (1 μmol/L) did not abolish the protective effect of nesfatin-1 (10−9 mol/L) on caspase-3 activation induced by MPP+. *P < 0.05 compared with the control group. #P < 0.05 compared with the MPP+-treated group. (MPP+:1-methyl-4-phenylpyridillium ion, PKA: protein kinase A).