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. 2017 Jan 20;7:40866. doi: 10.1038/srep40866

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Copyright © 2017, The Author(s)

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(A) Paired pulse ratios (PPRs, 2^nd eEPSC amplitude/1^st eEPSC amplitude) in the LHb were decreased in the ZT8(ZT7) group vs. the ZT2(ZT1) group (p < 0.01). The average PPR was 0.99 ± 0.06 (35 cells from 13 animals) in the LHb of the ZT2(ZT1) group and 0.67 ± 0.03 (37 cells from 17 animals) in the ZT8(ZT7) group. PPRs measured in the hippocampus (Hpp) remained comparable between the ZT2(ZT1) and ZT7 groups (p > 0.4). The mean PPR measured in the hippocampus of the ZT2(ZT1) group was 2.07 ± 0.10 (27 cells from 8 animals) vs. 1.97 ± 0.09 in the ZT8(ZT7) group (29 cells from 4 animals) (scale bar: 50 ms and 50 pA). (B) The box-plots show the ranges of the measured PPRs in the LHb and the hippocampus. (C) The failure rate of eEPSCs upon minimal stimulation in the LHb was 64.8 ± 4.1% in the ZT2(ZT1) group (18 cells from 5 animals) and 44.9 ± 5.9% in the ZT8(ZT7) group (17 cells from 7 animals). The failure rate was significantly lower in the ZT8(ZT7) group compared to the ZT2(ZT1) group (p < 0.01) (scale bar: 10 ms and 5 pA). (D) The rectification index (RI, eEPSC amplitude at 40 mV/eEPSC amplitude at −60 mV) of the LHb remained unchanged over time (p > 0.8, n = 8–9). The eEPSC amplitude at each holding potential was normalized to the eEPSC amplitude at −60 mV (scale bar: 20 ms and 100 pA). Representative traces are shown at the top of each panel.