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. 2017 Jan 20;7:39833. doi: 10.1038/srep39833

Figure 1. Schematic representations of the framework of an oxygen sensitive multichain CAR.

Figure 1

(A) Organization of the engineered mcCAR based on FcεRI. (B) Design of the alpha chains that integrate an oxygen sensitive domain, leading to the three HIF-CARs. The following domains of HIF1α are shown: BHLH: basic helix-loop-helix domain, PAS: Per-Arnt-Sim homology domain, PAC: PAS-associated C-terminal domain, ODD: Oxygen-Dependent Degradation domain, N-TAD: N-terminal Transactivation Domain, C-TAD: C-terminal Transactivation Domain, N-VHL: N-terminal von Hippel–Lindau recognition site, ID: inhibitory domain and C-VHL: C-terminal von Hippel–Lindau recognition site. Reproduced with permission from Cellectis Group.