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. 2017 Jan 20;7:40596. doi: 10.1038/srep40596

Table 3. List of parameters.

S.No. Notation Description Values Reference
1. K1 Rate constant for binding of Gsk3 to Axin2 0.23 nMmin−1 16
2. K2 Rate constant for dissociation of Gsk3-Axin2 0.1 min−1 16
3. K3 Rate constant of β-catenin synthesis 0.087 nMmin−1 16
4. K4 Rate constant of β-catenin entry into the nucleus 0.7 min−1 16
5. K5 Rate constant of β-catenin exit from the nucleus 1.5 min−1 16
6. K6 Rate constant of phosphorylation of β-catenin by the Gsk3 5.08 nMmin−1 16
7. K7 Concentration of Dishevelled(Dsh)protein 2.0 nM 16
8. K8 Total Gsk3 Concentration 3.0 nM 16
9. K9 Rate constant of inhibition by Dsh forβ-cateninP by the Axin2-Gsk3 complex 0.5 nM 16
10. K10 Michaelis rate constant for β-cateninp by the Axin2-Gsk3 complex 0.28 nM 16
11. K11 Maximum rate constant of dephosphorylation of β-catenin 1.0 nMmin−1 16
12. K12 Maximum rate constant for β-catenin phosphoration 0.003 nM 16
13. K13 Rate constant for degradation of unphosphorylated β-catenin 0 16
14. K14 Rate constant for degradation of phosphorylated β-catenin 7.062 min−1 16
15. K15 Rate constant of transcription of the Axin2 gene 0.06 nMmin−1 16
16. K16 Rate constant of transcription of the Axin2 gene induced by nuclear β-catenin 1.64 nMmin−1 16
17. K17 Rate constant for induction by nuclear β-catenin of Axin2 gene trascription 0.7 nM 16
18. K18 Maximum rate constant of degradation of Axin2 mRNA 0.8 nMmin−1 16
19. K19 Rate constant for degradation of Axin2 mRNA 0.48 nM 16
20. K20 Rate constant of transcription of Axin2 gene induced by transcription factor 0.5 nMmin−1 16
21. K21 Rate constant for induction by transcription factor of Axin2 gene transcription 0.05 nM 16
22. K22 Rate constant of synthesis of Axin2 protein 0.02 min−1 16
23. K23 Maximum rate constant of degradation of Axin2 protein 0.6 nMmin−1 16
24. K24 Michaelis rate constant for degradation of Axin2 protein 0.63 nM 16
25. K25 Hill coefficient 2.0 16
26. k26 Scaling factor for Wnt oscillator 1.5 16
27. k27 Rate constant of Mdm2 synthesis 0.297 min−1 19
28. k28 Rate constant of Mdm2 transcripton 0.006 min−1 19
29. k29 Rate constant of Mdm2 mRNA degradation 0.006 min−1 19
30. k30 Rate constant Mdm2 degradation 0.2598 min−1 19
31. k31 Rate constant of p53 synthesis 4.68 min−1 19
32. k32 Rate constant of p53 degradation 0.0495 min−1 19
33. k33 Rate constant of p53-Mdm2 binding 0.693 min−1 19
34. k34 Rate constant of p53-Mdm2 dissociation 0.00693 min−1 19
35. k35 Rate constant of Nutilin formation 0.001 min−1 Estimated
36. k36 Rate constant of Nutilin-Mdm2 formation 0.012 min−1 Estimated
37. k37 Rate constant of Nutilin-Mdm2 dissociation 0.03 min−1 Estimated
38. k38 Rate constant of Nutilin degradation 0.06 min−1 Estimated
39. k39 Rate constant of p53-Gsk3 complex formation 0.04 min−1 76
40. k40 Rate constant of p53-Gsk3 complex dissociation 0.12 min−1 76
41. k41 Rate constant of Mdm2 mRNA synthesis 0.042 min−1 76
42. k42 Rate constant of activation of Dsh by Wnt 5.0 min−1 25
43. k43 Wnt protein concentration 5.0 min−1 25
44. k44 Michaelis rate constant for activation of Dsh by Wnt 1.5 min−1 25
45. k45 Michaelis rate constant for activation of Dsh 0.95 min−1 25
46. k46 Rate constant of activation of inactivation of Dsh 1.0 min−1 25
47. k47 Michaelis rate constant for inactivation of Dsh 0.647 min−1 25
48. k48 Bimolecular rate constant for complex formation of Asin2 and Dsh 0.9 min−1 25
49. k49 Bimolecular rate constant for complex formation of β-catenin to Lef1 protein 0.9 min−1 25
50. k50 Bimolecular rate constant for degradation of complex of β-catenin to Lef1 protein 0.9 min−1 25
51. k51 Apparent first-order rate constant for the formation of Delta protein 0.1 min−1 25
52. k52 Maximum rate constant of degradation of Delta protein 0.9 min−1 25
53. k53 Michaelis rate constant for degradation of Delta protein 5.0 min−1 25
54. k54 Maximum rate constant of transcription of Delta gene induced by the complex of β-catenin and Lef1 in nucleus 1.12 min−1 25
55. k55 Maximum rate constant of degradation of mRNA of Delta protein in cytoplasm 2.0 min−1 25
56. k56 Michaelis rate constant for degradation of mRNA of Delta protein in cytoplasm 1.0 min−1 25
57. k57 Basal rat constant of transcription of the delta gene 1.0 min−1 25
58. k58 Apparent first-order rate constant for mRNA of Delta protein exit from the nucleus 1.725 min−1 25
59. k59 Apparent first-order rate constant for mRNA of Axin2 exit from the nucleus 2.0 min−1 25
60. k60 Maximum rate constant of degradation of mRNA of Axin2 in cytoplasm 1.2 min−1 25
61. k61 Michaelis rate constant for degradation of mRNA of Axin2 in cytoplasm 0.48 min−1 25
62. k62 Threshold rate constant for transcription of Delta induced by the complex of β-catenin and Lef1 protein in nucleus 2.46 min−1 25
63. k63 Threshold rate constant for transcription of Axin2 induced by the complex of β-catenin and Lef1 protein in nucleus 2.46 min−1 25
64. k64 Maximum rate constant of formation of Notch 0.23 min−1 16
65. k65 Maximum rate constant of degradation of Notch 2.82 min−1 16
66. k66 Michaelis rate constant for degradation of Notch 1.4 min−1 16
67. k67 Apparent first-order rate constant for Notch cleavage into NICD 3.45 min−1 16
68. k68 Maximum rate constant of degradation of NICD 0.01 min−1 16
69. k69 Michaelis rate constant for degradation of NICD 0.001 min−1 16
70. k70 Maximum rate constant of degradation of nuclear NICD 0.01 min−1 16
71. k71 Michaelis rate constant for degradation of nuclear NICD 0.001 min−1 16
72. k72 Threshold rate constant for inhibition of Notch cleavage into NICD by Lunatic fringe 0.5 min−1 25
73. k73 Apparent first-order rate constant for NICD entry into nucleus 0.1 min−1 16
74. k74 Apparent first-order rate constant for NICD exit from the nucleus 0.1 min−1 16
75. k75 Maximum rate constant of transcription of Lunaticfringe gene 3.0 min−1 16
76. k76 Threshold rate constant for activation of Lunaticfringe gene transcription by nuclear NICD 0.05 min−1 16
77. k77 Maximum rate constant of degradation of Lunaticfringe mRNA 1.92 min−1 16
78. k78 Michaelis rate constant of degradation of Lunaticfringe mRNA 0.768 min−1 16
79. k79 Apparent first-order rate constant for Lunatic fringe protein synthesis 0.3 min−1 16
80. k80 Maximum rate constant of Lunatic fringe protein degradation 0.39 min−1 16
81. k81 Michaelis rate constant of degradation of Lunatic fringe protein 0.37 min−1 16
82. k82 Inhibition constant for Gsk3 inhibition of Lunaticfringe transcription induced by NICD 2.5 min−1 25
83. k83 Hill coefficients for Notch oscillator 2.0 16
84. k84 Scaling factor for Notch oscillator 0.3 16
85. k85 Bimolecular rate constant for complex formation of NICD and Dsh 0.5 min−1 25
86. k86 Bimolecular rate constant for degradation of complex of NICD and Dsh 9.0 min−1 25