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. 2017 Jan 11;6:32. [Version 1] doi: 10.12688/f1000research.9838.1

Figure 1. Model outlining how STAT5 activation (pSTAT5) contributes to the differentiation of naïve CD4 T cells into various T helper (TH) subsets.

Figure 1.

In TH1 development, STAT5 drives interleukin 12 receptor beta 2 subunit (IL12Rβ2) expression. For TH2, STAT5 drives upregulation of IL4Rα. For TH9, STAT5 activation is required for IL9 production. In T helper type granulocyte-macrophage colony-stimulating factor (TH GM), STAT5 is critical for granulocyte-macrophage colony-stimulating factor (GM-CSF) production. STAT5 opposes the activation of STAT3, which is required for TH17 differentiation. STAT5 downregulates Bcl6 expression to inhibit T follicular helper (TFH) cell differentiation, and in regulatory T cells STAT5 turns on Foxp3 as well as CD25.