Figure 6.

AFM images of cytoplasmic dynein/dynactin complex bound to microtubules. In AFM images of dynein bound along the sides of microtubules, the mass of the motor complex is observed to associate more closely with the filament than is seen in images of dynein/dynactin binding to neurofilaments. (a) A height image; (b) the corresponding amplitude image; (c) a 3D conversion of the black square shown in panel a. (d) No binding of dynein/dynactin to microtubules was observed in the presence of Mg-ATP.