Table 2.
Association of the lipoprotein lipase single nucleotide polymorphisms (SNPs) with HDL-C levels
| Association of the SNPs with HDL-C levels (continuous variable) | ||
| SNP | HDL-C levels (means ± SD) | |
| SNP rs4922115 | ||
| GG | 1.1 ± 0.3 | |
| GA | 1.1 ± 0.2 | |
| AA | 1.1 ± 0.2 | |
| Dominant model (GG vs GA + AA) (P value) | 0.02 | |
| SNP rs1121923 | ||
| CC | 1.1 ± 0.3 | |
| CT | 1.2 ± 0.3 | |
| TT | 1.0 ± 0.2 | |
| Dominant model (CC vs CT + TT) (P value) | 0.02 | |
| SNP rs328 | ||
| CC | 1.1 ± 0.3 | |
| CG | 1.2 ± 0.3 | |
| GG | 1.2 ± 0.2 | |
| Dominant model (CC vs CG + GG) (P value) | 0.0004 | |
| SNP rs285 | ||
| CC | 1.1 ± 0.3 | |
| CT | 1.1 ± 0.2 | |
| TT | 1.2 ± 0.2 | |
| Dominant model (CC vs CT + TT) (P value) | 0.03 | |
| Association of the SNPs with HDL-C (categorical variable) | ||
| Low HDL-C levels Number (%) | Normal HDL-C levels Number (%) | |
| SNP rs4922115 | ||
| GG | 366 (65%) | 497 (71.3%) |
| GA | 171 (30.4%) | 167 (25.3%) |
| AA | 26 (4.6%) | 24 (3.4%) |
| Dominant model (GG vs GA + AA) (P value) | 0.02 | |
| SNP rs1121923 | ||
| CC | 530 (91.7%) | 642 (84.7%) |
| CT | 45 (7.8%) | 112 (14.8%) |
| TT | 3 (0.5%) | 4 (0.5%) |
| Dominant model (CC vs CT + TT) (P value) | 0.1 | |
| SNP rs328 | ||
| CC | 336 (78.3%) | 540 (69.8%) |
| CG | 88 (20.5%) | 215 (27.8%) |
| GG | 5 (1.2%) | 19 (2.5%) |
| Dominant model (CC vs CG + GG) (P value) | 0.001 | |
| SNP rs285 | ||
| CC | 336 (45.6%) | 421 (38%) |
| CT | 330 (44.8%) | 515 (46.5%) |
| TT | 71 (9.6%) | 171 (15.4%) |
| Dominant model (CC vs CT + TT) (P value) | 0.001 | |
HDL-C High density lipoprotein cholesterol
P values are adjusted for age, gender, body mass index, and Type 2 diabetes status
Those p values that are in bold implicates those values that are significant after Bonferroni correction