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. 2017 Jan 19;17:24. doi: 10.1186/s12862-016-0863-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Model for regulation and function of CYP26 genes in amphioxus. The position of the functionally validated retinoic acid response elements (RAREs) within the amphioxus CYP26 cluster is indicated relative to the start codons of the three amphioxus CYP26 genes (CYP26-1, CYP26-2, and CYP26-3). The relative expression of each of the genes is indicated during normal development (normal levels of RA and active RAR/RXR receptor heterodimers) as well as during exposure to RA (high levels of RA and active RAR/RXR receptor heterodimers), hence highlighting the dominance of CYP26-2 during normal development and the importance of CYP26-1 and CYP26-3 for protection against RA teratogenesis