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. 2017 Jan 20;7:8. doi: 10.3389/fcimb.2017.00008

Figure 2.

Figure 2

The dynamics of fungal infection in Tm-infected TLR2+/+ and TLR2−/− mice. (A) Recovery of viable fungi from footpads of Tm-infected mice 24 h and 7 days p.i. Results are expressed as mean ± SD (Unpaired t-test: ***P < 0.001). (B) Footpad of a naïve mouse (HE). (C) Footpad of a TLR2+/+ mouse 24 h after inoculation, showing a typical acute inflammatory response, characterized by an influx of neutrophils, edema, and abscess formation (HE). (D) Footpad of a TLR2+/+ mouse 7 days after infection, showing an initial granulomatous reaction with a small number of neutrophils and modified macrophages; details are shown in (E) (HE). (F) Footpad of a TLR2−/− mouse 7 days after infection, showing a well-organized granulomatous response, characterized by modified macrophages and epithelioid cells (arrow) (HE).