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. 2017 Jan 20;7:8. doi: 10.3389/fcimb.2017.00008

Figure 7.

Figure 7

The dynamics of fungal infection in HH-Tm TLR2+/+ and TLR2−/− mice. (A) Recovery of viable fungi from footpads of HH-Tm mice 24 h and 7 days p.i. Results are expressed as means ± SD. Unpaired t-test: *P < 0.05. (B) Footpad of a TLR2+/+ HH infected mouse 24 h p.i. exhibiting the initial inflammatory pattern characterized by intense polymorphonuclear infiltrate and edema (HE). (C) Footpad of a TLR2−/− HH infected mouse 24 h p.i. exhibiting the initial inflammatory pattern characterized by intense polymorphonuclear infiltrate and edema (HE). (D) Footpad of a TLR2+/+ HH infected mouse on day 7 p.i. showing a mixed inflammatory infiltrate with a small number of differentiated macrophages and an intense influx of neutrophils (HE). (E) Footpad of a TLR2+/+ HH infected mouse showing abscess formation and necrosis (HE). (F) Footpad of a TLR2−/− HH infected mouse on day 7 p.i., showing more organized granulomas, with a small number of neutrophils, and the presence of modified macrophages (HE).