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Model for the function of DmBlm in DSB repair. (Upper) The intermediate after strand invasion and repair synthesis. DmBlm functions at the junction marked by the arrowhead to unwind the invading strand. The resulting single-stranded DNA can then anneal to a complementary strand (Lower Left). In the absence of DmBlm, an endonuclease cleaves the invading strand at the arrowhead. The result (Lower Right) is a double-stranded deletion of sequences adjacent to the original DSB site.
