Table 2.
Flea count data for primary cats in the fluralaner topical and fipronil/(S)-methoprene groups. No efficacy comparison was performed at V1 and no primary cats had 90% reduction or were flea-free at V1
| Visit 1 (enrollment) |
Visit 2 (Week 4, Day 28) |
Visit 3 (Week 8, Day 56) |
Visit 4 (Week 12, Day 84) |
|
|---|---|---|---|---|
| Number of primary cats | ||||
| Fluralaner topical solution | 116 | 114 | 106 | 105 |
| Fipronil/(S)-methoprene spot-on solution | 45 | 40 | 38 | 34 |
| Arithmetic mean flea count (95% CI) | ||||
| Fluralaner topical solution | 47.8 (36.5–59.1) | 0.7 (0.1–1.3) | 0.4 (0.0–1.0) | 0.6 (0.3–0.9) |
| Fipronil/(S)-methoprene spot-on solution | 83.0 (24.7–141.2) | 37.1 (14.5–59.7) | 28.6 (14.3–42.9) | 20.4 (10.0–30.8) |
| P-value for comparisona | t (158.9) = -1.71, P = 0.0899 | t (160.5) = -5.17, P < 0.0001 | t (155.8) = -6.35, P < 0.0001 | t (148.4) = -6.88, P < 0.0001 |
| % efficacy (reduction from baseline) based on arithmetic means | ||||
| Fluralaner topical solution | na | 98.6 | 99.1 | 98.7 |
| P-value for comparison to baselinea | na | t (158.5) = 5.51, P < 0.0001 | t (159.2) = 4.74, P < 0.0001 | t (159.1) = 4.50, P < 0.0001 |
| Fipronil/(S)-methoprene spot-on solution | na | 55.2 | 65.5 | 75.4 |
| P-value for comparison to baselinea | na | t (160.4) = 3.49, P = 0.0006 | t (159.9) = 3.50, P = 0.0006 | t (159.6) = 3.75, P = 0.0002 |
| Geometric mean flea count (95% CI) | ||||
| Fluralaner topical solution | 28.0 (23.2–33.8) | 0.2 (0.1–0.4) | 0.1 (0.0–0.2) | 0.3 (0.2–0.4) |
| Fipronil/(S)-methoprene spot-on solution | 28.0 (19.2–40.9) | 15.0 (9.5–23.3) | 9.4 (5.2–16.4) | 6.8 (3.6–12.1) |
| P-value for comparisona | t (139.9) = 0.07, P = 0.9474 | t (139.7) = -17.56, P < 0.0001 | t (144.7) = -13.23, P < 0.0001 | t (139.3) = -10.80, P < 0.0001 |
| % efficacy (reduction from baseline) based on geometric means | ||||
| Fluralaner topical solution | na | 99.1 | 99.5 | 99.0 |
| P-value for comparison to baselinea | na | t (151.9) = 32.41, P < 0.0001 | t (150.8) = 30.60, P < 0.0001 | t (147.1) = 29.81, P < 0.0001 |
| Fipronil/(S)-methoprene spot-on solution | na | 46.5 | 66.6 | 75.8 |
| P-value for comparison to baselinea | na | t (159.3) = 3.96, P = 0.0001 | t (155.9) = 6.11, P < 0.0001 | t (158.4) = 7.68, P < 0.0001 |
| % of primary cats with at least 90% reduction from baseline flea count | ||||
| Fluralaner topical solution | na | 93.9 | 96.2 | 93.3 |
| Fipronil/(S)-methoprene spot-on solution | na | 10.0 | 31.6 | 38.2 |
| P-value for comparisonb | na | Z = -10.17, P < 0.0001 | Z = -7.26, P < 0.0001 | Z = -6.96, P < 0.0001 |
| % of flea-free primary cats | ||||
| Fluralaner topical solution | na | 80.7 | 88.7 | 80.0 |
| Fipronil/(S)-methoprene spot-on solution | na | 5.0 | 21.1 | 23.5 |
| P-value for comparisonb | na | Z = -8.45, P < 0.0001 | Z = -7.87, P < 0.0001 | Z = -6.05, P < 0.0001 |
Abbreviation: na value or calculation is not applicable
a P-value for comparison of model least squares means parameter estimates
b P-value for comparison of percentages using non-parametric asymptotic approach and Standardized Statistic