μCT analysis of femoral bones. The trabecular structural parameters were calculated for 100-day-old untreated Akp2+/+ mice (n = 3), ALP-BMC-treated Akp2−/− mice (n = 3), and mock-BMC-treated Akp2−/− mice (n = 2). BMD, bone mineral density; BV/TV, bone volume/total volume; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Spac, trabecular spacing; Tb.Th, trabecular thickness. Horizontal bars represent the mean values for each group.