Supplementary Table 2.
The top 10 transcription factors regulated DEGs in lung SCC.
| TFs | Log2FC | Up/down | Connectivity | Genes |
|---|---|---|---|---|
| NFIC | −0.9414 | Down | 83 | FGFR4, FCGRT, CHAF1A, HSD17B4, TMEM69, PLK1, ROBO4, CBLC, GPR116, NAA50, ARHGAP6, MCM6, DTYMK, PTPRM, RPS6KA2, CHRNA5, CYYR1, WDR62, ASF1B, GNGT1, TFB2M, GSTM5, ANLN, FLAD1, DNAJB11, MUSTN1, C10orf32, LRRC36, ECT2, PPP1R14B, ALDH2, CRY2, ARC, RNASE4, KRT74, FOXE1, BRCA1, SOX17, C5AR1, FKBP4, POC1A, C1orf162, RNASE1, SLC7A5, FAM72A, CBX7, PGM5, PCDH12, SSX2IP, TM6SF1, PALM2-AKAP2, ACOXL, PITX2, PSAT1, FZD4, DSP, UTRN, KIF22, CENPE, TMEM189, FAM72D, TMEM132A, TERT, DLX6, KIF1C, STX12, GORASP1, ATAD5, TK1, LRRK2, GGCT, KIF11, LMNB1, SLC25A10, ZC3H8, TRPV2, POLR2H, CALCRL, MMRN1, CD34, MMP11, CDC25A, RAB8B |
| BRCA1 | 2.0335 | Up | 82 | LIMD1, CELF2, ACACB, CD302, DUSP9, PPAP2C, GORASP1, LAMP3, MCM4, GYLTL1B, FLAD1, TNS4, HSD17B4, STRA6, FAM83D, DAPK2, MARCO, EFNA4, PDE1B, PSRC1, COL4A3, ASAH1, TIMM8A, ERCC6L, CBLC, SORBS1, HOPX, CCDC58, CLEC14A, PLEKHO2, BTBD9, PALB2, KIF4A, SSX2IP, SPOCK2, EDNRB, ADAMTSL4, PTH1R, GGCT, UBE2T, HELLS, ABCC6, ADCY9, NEK2, PHACTR1, TPK1, TROAP, ABCA12, TMPRSS11F, CENPK, PRPF19, ATP11A, TOP2A, SNRPA1, SUV39H2, DSP, SACM1L, HDAC2, ELTD1, TPX2, B4GALNT4, TNXB, GCOM1, PID1, HBB, MYO19, AATK, NLRC4, BLM, SH3BP5, GIMAP6, GLIPR2, GNAQ, MELK, MND1, SKA3, ADAMTS8, RPS6KA2, CHAF1A, ITGA10, CALCOCO1 |
| NFATC2 | −2.5949 | Down | 75 | IGSF9, SH3BP5, KRT16, PTHLH, PTPN21, CARD8, PSMD12, MELK, GPIHBP1, RAD51AP2, DUSP1, TSPAN12, PKMYT1, PSMC3IP, KANK2, ALDH3B1, ARTN, MYO19, NUDT1, PLAC9, HOXD13, FANCI, AKAP13, KIAA1524, KIF20A, DTYMK, DEPDC1B, VEPH1, PDE1B, NMU, MRPL47, STIL, ASPM, UBE2T, FEN1, SASH1, BIRC5, PLEKHO2, LRRN3, DSCC1, PXMP4, CASS4, MMP12, MARCO, E2F1, FAM162B, SULT1A1, PCDH12, FBLN5, TRAF7, PNPLA6, KIAA0101, FILIP1, DOK2, FAM72B, CBLC, B3GNT4, TPBG, WWC2, C1orf162, KRT17, KIF18B, RASAL1, C20orf202, PRKCE, CCNB2, ABCA9, ADAMTS8, GAL, LAMP3, RHOA, ADARB1, SCUBE1, NCAPG, TCF19 |
| NR4A2 | −2.4142 | Down | 64 | NOVA2, FAM105A, PTPRB, SASS6, GPR4, ARHGAP29, RSRC1, DQX1, SCUBE1, MRPL47, ALDH3B1, PDE2A, POLQ, ALDH2, APOBEC3B, SLC46A2, FRY, E2F2, PITX2, GINS3, C10orf2, CENPL, RAI2, ACP5, CDC25C, SSX2IP, NCAPG2, ATAD2, YWHAZ, E2F7, IRF6, SRD5A1, MCM2, DENND3, NAA50, POC1A, EDNRB, TFAP2A, CDCA8, CCNB2, B3GALNT2, KIF11, CBLC, TMEM100, GIMAP8, CDC25A, COX4I2, CDH5, MELK, FAM131C, TMPRSS11F, PREX2, TPK1, PLEKHG6, GPR87, CSTF2, UHRF1, KIAA1462, KANK3, ADPRH, PGM5, MCM6, CCDC69, MITF |
| EGR1 | −2.1270 | Down | 45 | CLEC3B, SHOX2, EPB41L5, C1QTNF7, PRIM2, SUV39H2, RSRC1, VEPH1, HYAL2, TRIM29, ACACB, TPBG, TMEM79, DOK2, PTPRM, GUCA1A, CX3CR1, SPOCK2, BCL6B, CDCA5, FAM83B, CABLES1, FANCI, TNXB, RIMS2, GRHL1, GPR133, DLL4, WWC1, ENG, UHRF1, ABI3BP, UTRN, PNPLA6, SNRK, ST6GALNAC6, SEMA3B, MEX3A, PDE2A, FAM13C, RASL12, SLC2A1, TMEM132A, ATP11A, WFS1 |
| ELF5 | −2.5991 | Down | 43 | ESPL1, RBPMS, GABRA3, DEPDC1B, C1orf112, GJB3, VIPR1, RAB27A, UBL3, FBXO45, MUSTN1, SH3D19, ZIC5, PALM2-AKAP2, KLF9, LIMD1, NUSAP1, GNAI2, DRAM1, AFAP1L1, BTBD9, SLC16A1, DSC3, NR5A2, RHOJ, SH2D3C, HSPB6, PID1, FLI1, RXFP2, ADCY9, SORBS1, PRKCE, DCAF13, TP63, RHOA, FARSB, CCT3, SYT15, CALCRL, ABI3BP, PRIM2, WDR62 |
| HOXA5 | −2.0075 | Down | 43 | CENPF, CACNA2D2, NOL10, CCDC34, MELK, PAFAH1B3, ADCY9, RECK, CENPH, FAM105A, SHROOM4, LEPR, GRK5, UNC13B, SRPK1, HDAC1, SGOL1, MYCT1, MARCO, NPR1, SLC1A1, EPAS1, MITF, C12orf49, CYYR1, ATAD2, CCDC58, FANCD2, GPD1L, MCM8, DENND3, ESRP1, MTL5, LMNB2, RRM2, SCUBE1, HOXA10, S1PR1, LTA4H, CDC45, HDAC2, RAB27A, AFAP1L1 |
| FOXD1 | 3.7626 | Up | 42 | SGOL1, TNFSF12, MS4A15, ESCO2, GORASP1, CYB5A, EPAS1, FANCE, GPR116, LRRN3, RAD51AP1, ROBO4, PSMD12, KCNAB1, MTIF2, MBIP, CCDC34, HSD17B11, CABLES1, GRHL2, ELTD1, SHOX2, CAV1, KRTAP4-1, UHRF1, GPRIN1, GPD1L, DSG3, NEK2, YWHAZ, PEAR1, SNX2, COL4A3BP, CDC6, ARHGAP31, CENPO, CLSPN, KIF23, DSC3, SLC7A5, RPS6KA2, ADARB1 |
| ZEB1 | −1.8558 | Down | 40 | TNS4, CDC45, NMU, IQGAP3, ACSM2A, TNXB, MYO19, C12orf56, UNG, ARHGAP18, CFD, CENPF, SPTBN2, AATK, CASC5, PECAM1, FLVCR2, NR4A1, SUSD2, PALB2, DNAJB11, FAM83F, TNFSF12, SPATS2, RIMS2, SPNS2, PRAME, TNFSF13, MRPL3, MYCT1, HN1L, RAI2, DCUN1D5, SNX30, KIF15, FGFR4, DTL, FOXE1, MARCO, ANLN |
| KLF5 | 1.1064 | Up | 34 | EZH2, MMP11, FLT4, FGR, MFNG, SNX2, JAM2, BOP1, CSRNP1, ZWILCH, LMNB2, PXMP4, ESPN, DUSP9, UHRF1, ADAMTSL4, LIMD1, CABLES1, DCAF13, CD97, TRAP1, PRX, UNG, KIF23, CDT1, GPRIN1, GMPS, MAP3K3, RASAL1, FGF11, ARHGAP29, RILPL2, E2F1, TSPAN4 |
TFs – transcription factors; FC – fold change; lung SCC – lung squamous cell carcinoma.