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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Metab Brain Dis. 2016 Feb 6;31(2):249–255. doi: 10.1007/s11011-016-9798-x

Table 1.

CD74 binding residues and their binding partner residues on one binding face of MIF vs. one RTL1000 construct.

CD74-TD Chain MIF/RTL1000
CD74-TD Chain A residues 118YGNMT122 (Yellow) MIF Chain A (White) residue K77; and MIF Chain B
(Light Grey) residues 108WNN110
CD74-TD Chain A residues 179RHSLE183 (Yellow) MIF Chain B (Light Grey) residues 111STFA114
CD74-TD Chain C 118YGNMT122 residues (Cyan) MIF Chain A (White) residues 50FGGS52 and
109NNS111; and Chain B (Light Grey) residues
34PQ35
CD74-TD Chain C residues 179RHSLE183 (Cyan) MIF Chain A (White) residues 49FGG51, S74, K77 &
90SPDR93
CD74-TD Chain B residues 118YGNMT122 (Pink) MIF Chain B (Light Grey) residues 108WNN110
CD74-TD Chain B residues 179RHSLE183 (Pink) MIF Chain A (White) residues 53SEP55
CD74-TD Chain A (Yellow) & Chain B (Pink) residues
118YGNMT122 and Chain A (Yellow) & Chain C
(Cyan) residues 179RHSLE183		 DRα1 (Light Blue) residues F12, L14, C16, D17 & S19
CD74 Chain C residues 118YGNMT122 (Cyan) and
Chain B residues 179RHSLE183 (Pink)		 DRα1 (Light Blue) residues Y79 & T80
CD74-TD Chain C residues 118YGNMT122 (Cyan) DR2β1 (Dark Blue) residue Q34