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Effect of 26 day treatment of donepezil (2.0 mg/kg/day) or rivastigmine (0.3 mg/kg/day) on brain clearance of exogenous 125I-Aβ40 across the BBB in young and aged rats. Brain efflux index (BEI%) of 125I-Aβ40 in young (A), and aged (B) rats treated with donepezil or rivastigmine. Data presented as mean ± SEM (n = 5, *P < 0.05, **P < 0.01, ***P < 0.001).
