Phenotypic characterization of SRC-2−/− mice during N/L and CCD conditions. (A) Body weight (grams), (B) percent body fat, and (C) percent lean mass of WT and SRC-2−/− mice subjected to N/L or CCD for 20 and 40 weeks, respectively. (D) Comparative 40× liver histology and immunohistochemistry for H&E, Oil-Red-O, F4/80, Ki-67, and trichrome staining from WT and SRC-2−/− mice subjected to N/L and CCD. (E) Plasma ALT of WT and SRC-2−/− mice subjected to N/L and CCD. (F) Plasma AST of WT and SRC-2−/− mice subjected to N/L and CCD. Data are graphed as the mean ± SEM. *p < 0.05. **p < 0.01. ***p < 0.001. (N = 3–4).