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. Author manuscript; available in PMC: 2017 Jan 20.
Published in final edited form as: J Biol Rhythms. 2016 Jul 17;31(5):443–460. doi: 10.1177/0748730416657921

Figure 4.

Figure 4

Gene set enrichment analysis (GSEA) of murine CCD hepatic transcriptomic data compared with human HCC microarray data. (A) (i) Heat map representation of liver microarray in WT and SRC-2−/− mice at ZT4 N/L. (ii) GSEA plot representation of upregulated and down-regulated genes in common between the HCC human hepatic microarray dataset and enriched relative to WT in the SRC-2−/− ZT4 N/L hepatic microarray. (iii) Normalized enrichment score of up-regulated and down-regulated genes from A(ii). (B) (i) Heat map representation of liver microarray in WT and SRC-2−/− mice at ZT4 CCD. (ii) GSEA plot representation of up-regulated and down-regulated genes in common between the HCC human hepatic microarray dataset and enriched relative to WT in the SRC-2−/− ZT4 CCD hepatic microarray. (iii) Normalized enrichment score of up-regulated and down-regulated genes from B(ii). (C) (i) Heat map representation of liver microarray in N/L and CCD WT mice at ZT4. (ii) GSEA plot representation of up-regulated and down-regulated genes in common between the HCC human hepatic microarray dataset and enriched relative to N/L in the CCD ZT4 WT mice hepatic microarray. (iii) Normalized enrichment score of up-regulated and down-regulated genes from C(ii). (D) (i) Heat map representation of liver microarray in N/L and CCD SRC-2−/− mice at ZT4. (ii) GSEA plot representation of up-regulated and down-regulated genes in common between the HCC human hepatic microarray dataset and enriched relative to N/L in the CCD ZT4 SRC-2−/− mice hepatic microarray. (iii) Normalized enrichment score of up-regulated and down-regulated genes from D(ii).