Table 2.
Regulated GAP and GEF proteins belonging to the Rho/Rac pathway
| GDP exchange proteins (GEF) | GTPase-activating proteins (GAP) | ||||||
|---|---|---|---|---|---|---|---|
| Accession | Gene | Site | Regulation | Accession | Gene | Site | Regulation |
| Q12802 | AKAP13 | Ser1750 | ↑10ADP | P98171 | ARHGAP4 | Ser860 | ↑10ADP |
| Ser2709 | ↑10ADP | ||||||
| Q92974 | ARHGEF2 | Ser121/122 | ↑10ADP | O43182 | ARHGAP6 | Ser927 | ↑10ADP |
| Ser820/Thr821 | ↓60ADP | ||||||
| Q14155 | ARHGEF7 | Ser674/676 | ↑30ADP | Q53QZ3 | ARHGAP15 | Ser43 | ↑30ADP |
| O15013 | ARHGEF10 | Ser379 | ↑10ADP | A7KAX9 | ARHGAP32 | Ser587 | ↑60ADP |
| Q9NZN5 | ARHGEF12 | Ser22 | ↑10ADP | Q92619 | HMHA1 | Ser14 | ↑10ADP |
| Ser599 | ↑10ADP | Ser73 | ↑10ADP | ||||
| Thr96/Ser99 | ↑10ADP | ||||||
| Q9H7D0 | DOCK5 | Ser1742 | ↑10ADP | Q13576 | IQGAP2 | Ser16 | ↑10ADP |
| Ser1766 | ↑10ADP | ||||||
| Ser1781 | ↑10ADP | ||||||
| Q96N67 | DOCK7 | Ser182 | ↑10ADP | Q13459 | MYO9B | Thr1271 | ↑10ADP |
| Ser1354 | ↓60ADP | ||||||
| Thr1492 | ↑10ADP | ||||||
| Ser1972 | ↑10ADP | ||||||
| Q5JSL3 | DOCK11 | Ser31 | ↑10ADP | O60890 | OPHN1 | Ser703 | ↑30ADP |
| O60229 | KALRN | Ser1896 | ↑10ADP | ||||
| Ser2261 | ↑10ADP | ||||||
| Ser1756 + 1757 | ↑10ADP | ||||||
| Q07890 | SOS2 | Ser1315 | ↑10ADP | ||||
| P21731 | TBXA2 | Ser329 | ↑30ADP | ||||
| Q9UKW4 | VAV3 | Ser786 | ↑10ADP | ||||
↑10ADP corresponds to upregulation after 10 seconds of ADP stimulation. If the phosphorylated site could not be localized to a distinct Ser/Thr/Tyr residue with high confidence (eg, ARHGAP6), all possibly phosphorylated residues are listed, according to the phosphoRS algorithm.