Table 3.

Multivariate Cox proportional hazards regression analysis for factors predictive for OS in RCC, mRCC, and subgroups of mRCC patients in Norway diagnosed between 2002 and 2011

Variable	RCC (N=5,463)		mRCC (n=1,678)
	HR (95% CI)a	P-value	HR (95% CI)b	P-value
Year of diagnosis
2002–2005	1.000	–	1.000	–
2006–2008	0.880 (0.797–0.972)	0.011	1.006 (0.877–1.153)	0.935
2009–2011	0.767 (0.687–0.856)	<0.001	0.911 (0.788–1.054)	0.209
Genderc
Female vs male	0.790 (0.723–0.864)	<0.001	0.894 (0.795–1.004)	0.059
Age, years
≤49	1.000	–	1.000	–
50–59	1.419 (1.162–1.732)	<0.001	0.975 (0.778–1.222)	0.824
60–69	1.916 (1.591–2.306)	<0.001	1.229 (0.993–1.522)	0.058
70–79	2.467 (2.056–2.960)	<0.001	1.287 (1.036–1.600)	0.023
≥80	2.765 (2.272–3.365)	<0.001	1.379 (1.068–1.781)	0.014
Prior nephrectomyc
Yes vs no	0.121 (0.109–0.133)	<0.001	0.463 (0.411–0.521)	<0.001
≥1 targeted therapy prescription dispensedc
Yes vs no	–	–	0.573 (0.505–0.651)	<0.001

Subgroup mRCC patients
Variable	Primary mRCC (n=1,048)		mRCC age 75+ (n=403)		Clear cell mRCC (n=1,453)
	HR (95% CI)b	P-value	HR (95% CI)b	P-value	HR (95% CI)b	P-value
Year of diagnosis
2002–2005	1.000	–	1.000	–	1.000	–
2006–2008	1.138 (0.962–1.347)	0.132	0.904 (0.695–1.176)	0.453	1.031 (0.888–1.196)	0.690
2009–2011	1.080 (0.900–1.296)	0.407	0.829 (0.622–1.104)	0.200	0.918 (0.784–1.073)	0.283
Genderc
Female vs male	0.910 (0.786–1.054)	0.210	0.936 (0.746–1.173)	0.564	0.919 (0.811–1.042)	0.187
Age, years
≤49	1.000	–	–	–	1.000	–
50–59	0.983 (0.741–1.305)	0.908	–	–	0.921 (0.719–1.178)	0.510
60–69	1.049 (0.806–1.366)	0.721	–	–	1.194 (0.944–1.510)	0.138
70–79	1.010 (0.771–1.322)	0.944	–	–	1.271 (1.001–1.613)	0.049
≥80	1.032 (0.756–1.408)	0.843	–	–	1.328 (1.000–1.762)	0.050
Targeted therapy combined with nephrectomy
Neither therapy	1.000	–	–	–	–	–
Nephrectomy only	0.350 (0.291–0.421)	<0.001	0.514 (0.406–0.651)d	<0.001	0.460 (0.405–0.524)d	<0.001
Targeted therapy only	0.402 (0.322–0.502)	<0.001	0.470 (0.347–0.636)e	<0.001	0.554 (0.483–0.635)e	<0.001
Both therapies	0.235 (0.189–0.292)	<0.001	–	–	–	–

Notes:

^aAdjusted for geographic region and histology.

^bAdjusted for geographic region.

^cFor binary variables, an HR <1 equates to risk reduction for the first category and an HR >1 equates to risk reduction for the second category.

^dNephrectomy yes vs no.

^eTargeted therapy yes vs no.

Abbreviations: CI, confidence interval; HR, hazard ratio; mRCC, metastatic renal cell carcinoma; OS, overall survival; RCC, renal cell carcinoma.