Table S1.
Multivariate Cox proportional hazards regression analysis of factors, including line of therapy, predictive for OS in mRCC patients in Norway diagnosed between 2002 and 2011
| Variable | mRCC (n=1,678)
|
|
|---|---|---|
| HR (95% CI)a | P-value | |
| Year of diagnosis | ||
| 2002–2005 | 1.000 | – |
| 2006–2008 | 0.980 (0.856–1.121) | 0.765 |
| 2009–2011 | 0.893 (0.775–1.030) | 0.120 |
| Genderb | ||
| Female vs male | 0.887 (0.789–0.997) | 0.044 |
| Age, years | ||
| ≤49 | 1.000 | – |
| 50–59 | 0.959 (0.764–1.202) | 0.714 |
| 60–69 | 1.159 (0.935–1.436) | 0.178 |
| 70–79 | 1.204 (0.968–1.498) | 0.095 |
| ≥80 | 1.304 (1.010–1.684) | 0.042 |
| Prior nephrectomyb | ||
| Yes vs no | 0.464 (0.412–0.522) | <0.001 |
| Line of therapy | ||
| No line | 1.000 | – |
| 1 line | 0.713 (0.621–0.818) | <0.001 |
| 2 lines | 0.574 (0.472–0.699) | <0.001 |
| 3+ lines | 0.369 (0.292–0.466) | <0.001 |
Notes:
a
Adjusted for geographic region.
b
For binary variables, an HR <1 equates to risk reduction for the first category and an HR >1 equates to risk reduction for the second category.
Abbreviations: CI, confidence interval; HR, hazard ratio; mRCC, metastatic renal cell carcinoma; OS, overall survival.