Figure 1.

Effects of cyclic stretch (CS) on expression of nonmuscle myosin light-chain kinase (nmMLCK) and splice variants. (A) Analysis of total nmMLCK mRNA. Levels of total nmMLCK were increased in response to 18% CS. Cells were exposed to CS for 8 hours, and control cells under static conditions were maintained in the same incubator. (B) Levels of nmMLCK1 versus nmMLCK2 in endothelial cells. Levels were normalized to nmMLCK1 under static conditions and demonstrate increased nmMLCK2 expression under 18% CS. Data are presented as mean ± SE of three independent experiments.