Table 1.
Top GWAS Variants Associated with Childhood and Lifetime Pneumonia*: Individual GWAS
| Individual GWAS | SNP | Nearest Gene | Locus | Rsq | Risk Allele | Frequency (%) | OR | P Value |
|---|---|---|---|---|---|---|---|---|
| NHW childhood pneumonia (n = 685 cases, 5,967 control subjects) | rs16833920 | MATN1† | 1p35.2 | 0.99 | G | 64.82 | 1.38 | 2.80E-07 |
| NHW lifetime pneumonia (n = 2,284 cases, 3,422 control subjects) | rs55762539 | MCPH1† | 8p23.1 | 0.78 | C | 42.45 | 1.22 | 8.28E-07 |
| AA lifetime pneumonia (n = 882 cases, 2,237 control subjects) | rs1107268 | LOC339862 | 3p24.3 | 0.95 | G | 25.32 | 1.38 | 8.67E-07 |
| rs140541031 | RAPGEF2 | 4q32.1 | 0.81 | A | 17.55 | 1.47 | 8.40E-07 | |
| rs34476983 | PHACTR1 | 6p24.1 | 0.86 | C | 87.12 | 1.66 | 6.06E-07 |
Definition of abbreviations: AA, African American; GWAS, genome-wide association study; NHW, non-Hispanic white; OR, odds ratio; Rsq, estimation of imputation quality; SNP, single-nucleotide polymorphism.
*
Includes the top SNP from each region where GWAS P value was ≤1 × 10−6.
†
SNP is near these genes, not in the genes.