Table 2.
Top GWAS Variants Associated with Childhood and Lifetime Pneumonia*: GWAS Meta-Analysis
| GWAS Meta-Analysis | SNP | Nearest Gene | Locus | NHW Rsq | AA Rsq | Risk Allele | NHW FRQ (%) | AA FRQ (%) | OR | P Value | I2 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Childhood pneumonia (n = 843 cases, 9,091 control subjects) | rs188808012 | NRG1 | 8p12 | 0.95 | 0.85 | T | 1.48 | 1.01 | 2.46 | 6.32E-08 | 65.44 |
| rs77554123 | PAK6 | 15q14.1 | 0.99 | 0.51 | A | 5.16 | 4.66 | 1.70 | 3.28E-07 | 37.09 | |
| Lifetime pneumonia (n = 3,766 cases, 5,659 control subjects) | rs56373127 | PRR27† | 4q13.3 | 0.93 | 0.93 | G | 41.59 | 25.29 | 1.18 | 4.34E-07 | 0 |
| rs11136992 | MCPH1† | 8p23.1 | 0.72 | 0.74 | T | 40.34 | 37.75 | 1.21 | 2.71E-07 | 15.36 |
Definition of abbreviations: AA, African American; FRQ, frequency; GWAS, genome-wide association study; I2, heterogeneity index; NHW, non-Hispanic white; OR, odds ratio; Rsq, estimation of imputation quality; SNP, single-nucleotide polymorphism.
*
Includes the top SNP from each region where GWAS P value was ≤1 × 10−6.
†
SNP is near these genes, not in the genes.