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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Biomech Eng. 2017 Feb 1;139(2):10.1115/1.4034991. doi: 10.1115/1.4034991

Figure 5.

Figure 5

Stress alleviation strategy improves perfusion in hypovascular orthotopic pancreatic AK4.4 and Capan2 tumors. A and B) Fluorescence images showing increased number of perfused vessels in saridegib treated tumors. Cd31 (green color) stains for all tumor vessels, while lectin (red color) stains only perfused vessels. C-F) Saridegib alleviates solid stress showed by the decrease in the tumor opening, decompresses both blood and lymphatic vessels, improves fraction of perfused vessels, without affected vascular density. +, saridegib; −, vehicle. The asterisks denote a statistically significant difference [Reproduced with permission from Reference [9]].