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Intraperitoneal glucose tolerance in ZnT8 RW T-12 (A) and ZnT8 WT X-40 (B) Tg+ and Tg− mice fed either an HFD or ND from 6 to 16 weeks of age. Six to 10 mice per group were tested for glucose tolerance at 16 weeks (1.5 mg glucose/g body weight), and blood glucose was measured at the indicated times after injection. *Significant difference from Tg− animals on the same diet at P < 0.05.
