Table 1.

Metabolic parameters in db/db mice and DIO mice

	db/db mice			DIO mice
Parameter	Control	Ad5E4ORF1	Ad36E4ORF1	Control	Ad5E4ORF1	Ad36E4ORF1
Serum glucose (mg/dL)	470 ± 61.2	424 ± 51.6	292 ± 32.4*	225.9 ± 16.0	182.3 ± 11.3*	172.8 ± 14.8*
Serum insulin (ng/mL)	17.7 ± 4.2	5.0 ± 1.4*	5.5 ± 2.1*	1.73 ± 0.22	1.01 ± 0.28	0.37 ± 0.21***
Serum cholesterol (mg/dL)	80.5 ± 9.4	83.2 ± 8.4	106.4 ± 9.8	176.9 ± 18.3	139.6 ± 12.2	168.4 ± 15.5
Serum triglycerides (mg/dL)	159.1 ± 36.9	102.8 ± 9.4	79.0 ± 9.4	99.8 ± 9.4	92.7 ± 10.3	59.7 ± 7.3**
Serum NEFA (mEQ/L)	0.45 ± 0.05	0.44 ± 0.06	0.41 ± 0.03	0.36 ± 0.03	0.31 ± 0.04	0.30 ± 0.04
Serum leptin (ng/mL)	49.3 ± 4.3	43.8 ± 4.3	51.2 ± 5.6	20.0 ± 1.0	14.2 ± 1.4**	3.8 ± 1.0***
Serum adiponectin (μg/mL)	6.4 ± 0.6	5.4 ± 0.5	4.4 ± 0.4*	12.0 ± 0.6	10.4 ± 0.4	8.2 ± 0.6***
Liver cholesterol (mg/g)	10.3 ± 1.3	13.5 ± 1.1	13.3 ± 1.0	15.6 ± 3.0	14.8 ± 3.1	16.1 ± 2.4
Liver triglycerides (mg/g)	149.1 ± 9.4	173.4 ± 9.4	186.6 ± 9.4	113.9 ± 38.5	136.8 ± 39.3	262.5 ± 21.8**
Liver NEFA (mEQ/g)	0.24 ± 0.02	0.20 ± 0.01	0.21 ± 0.3	0.16 ± 0.01	0.16 ± 0.01	0.15 ± 0.01
Liver glycogen (mg/g)	7.49 ± 0.73	5.94 ± 0.15	6.20 ± 0.28	5.40 ± 0.38	4.54 ± 0.34	2.86 ± 0.10**

Data are mean ± SEM. n = 8 per group in db/db experiment. n = 8 control, 8 Ad5E4ORF1, and 9 Ad36E4ORF1 in DIO experiment. NEFA, nonesterified fatty acid.

*P < 0.05,

**P < 0.01,

***P < 0.001 vs. control.