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. 2016 Dec 1;66(2):372–384. doi: 10.2337/db16-1102

Figure 6.

Figure 6

Disruption of the GLP-1R in Nkx2.1 neurons does not blunt the food intake–suppressive effect of peripherally dosed liraglutide but does impact the compound’s body weight–lowering effect in HFD-fed mice. A: The values are mean ± SEM and represent 16-h food intake following treatment with liraglutide (Lira) (200 µg, s.c.) in chow-fed GLP-1RKDΔNkx2.1cre (n = 9) mice, compared with GLP-1Rf/f controls (n = 17). Data are shown at 4-h intervals and expressed as a percentage of the food intake response observed following treatment with vehicle. B and C: The values are mean ± SEM and represent daily body weight over the course of 21 days in chow-fed (B) or HFD-fed (C) GLP-1RKDΔNkx2.1cre (n = 5–6), compared with GLP-1Rf/f controls (n = 8–11) treated with liraglutide. Data are expressed as a percentage of baseline (i.e., prior to liraglutide treatment) body weight. On days 0–13, morning body weight was measured, and animals received a twice-daily injection of liraglutide (200 µg/kg BW, s.c.) or vehicle. On recovery days 14–21, only morning body weight was measured. *P < 0.05 vs. saline. †P < 0.05 vs. GLP-1Rf/f.