Table 1.
The sources of data for creating the compendium of genes controlling human body weight and feeding behavior and characteristics of the corresponding gene sets
| Source of data/description of the gene set | Short name of the data source and the gene set | Number of genes | Number of publications or database query |
|---|---|---|---|
| Research papers and review articles on FB-regulating genes |
Publications
(Additional file 1: Table S1) |
105 | 17 review articles, 45 research papers |
| OMIM/genes possessing allelic variants associated with obesity, hyperphagia, or anorexia |
OMIM_allelic_variants
(Additional file 1: Table S2) |
73 | Command used in OMIM search: ‘hyperphagia’ OR ‘obesity’ OR ‘anorexia’ (Records with: gene map locus; Prefixes: +, *; Search in: allelic variants) |
| OMIM/terms obesity, or hyperphagia, or anorexia were found in text fields (excluding the chapter devoted to allelic variants). |
OMIM_all_text
a
(Additional file 1: Table S2) |
263 | Command used in OMIM search: ‘hyperphagia’ OR ‘obesity’ OR ‘anorexia’ (Records with: gene map locus; Prefixes: +, *; Search in: all text) * |
| OMIM and research papers/Genes whose mutant variants are implicated in the Bardet-Biedl and other syndromes associated with obesity. |
Syndromes
(Additional file 1: Table S3) |
37 | OMIM entries: 1) #209900; BARDET-BIEDL SYNDROME 1 (Genetic Heterogeneity of Bardet-Biedl Syndrome) 2) #176270; PRADER-WILLI SYNDROME 3) #203800; ALSTROM SYNDROME 4) #216550; COHEN SYNDROME 5) #103580; PSEUDOHYPOPARA-THYROIDISM, TYPE IA 6) #201000; CARPENTER SYNDROME 1 7) #147920; KABUKI SYNDROME 1; 8) #300867; KABUKI SYNDROME 2; 9) #157980; MOMO SYNDROME 10) #301900; BORJESON-FORSSMAN-LEHMANN SYNDROME 11) #182290; SMITH-MAGENIS SYNDROME 12) #180849; RUBINSTEIN-TAYBI SYNDROME 1 13) #612469; WAGRO SYNDROME; 3 review articles, 1 research paper |
| GWAS meta-analysis papers/genes located in the vicinity of a lead SNP |
GWAS meta-analysis
(Additional file 1: Table S4) |
184 | 9 research articles |
aThe set OMIM_all_text included genes for which at least one of query terms was found in any chapter other than that on allelic variants but the latter contained none of the terms. If the query term was also found in the chapter on allelic variants, such gene was assigned to the set OMIM_allelic_variants and excluded from OMIM_all_text