Table 2.

Overrepresented (BH adjusted p-value < 0.05) GO terms (biological processes, molecular functions, cellular compartments) that characterize functional groups of genes presented in Fig. 2b.

Functional group	GO category	GO class	Number of genes from the compendium annotated by the category	Fold Enrichment	BH adjusted p-value
Transmembrane receptors	GO:0004888 ~transmembrane receptor activity	Molecular function	89	2.09	1.6E-09
Transcription factors	GO:0003700 ~ transcription factor activity	Molecular function	52	1.63	1.1E-02
Signaling molecules (hormones, neuropeptides, cytokines, etc.)	GO:0005179 ~ hormone activity	Molecular function	37	10.48	1.5E-24
	GO:0005184 ~ neuropeptide hormone activity	Molecular function	15	19.95	7.6E-14
	GO:0005125 ~ cytokine activity	Molecular function	16	2.51	3.2E-02
Signal transduction	GO:0004871 ~ signal transducer activity	Molecular function	139	1.87	3.2E-12
Cilium or BBSome	GO:0060271 ~ cilium morphogenesis	Biological process	10	8.77	1.5E-05
	GO:0034464 ~ BBSome	Cellular component	7	31.56	1.8E-07
Lipid localization	GO:0008289 ~ lipid binding	Molecular function	34	2.31	3.9E-04
Transcriptional coregulators	Nonea
Enzymes (regulatory)	None
Enzymes (metabolic)	None

The list of 578 genes from the compendium was analyzed with the DAVID-tool. The significance level for the BH adjusted p-value was 0.05

^aNone – No overrepresented GO terms were found