Table 3.
Genes differentially expressed in ISIAH versus WAG renal medulla and annotated in Rat Genome Database as associated with kidney diseases
| Gene symbol | NCBI gene ID | Gene name | log2 fold change ISIAH/WAG |
|---|---|---|---|
| Acsm3 | 24763 | acyl-CoA synthetase medium-chain family member 3 | 3.40 |
| Adipoq c,d | 246253 | adiponectin, C1Q and collagen domain containing | 1.17 |
| Agtr1a a,c,d | 24180 | angiotensin II receptor, type 1a | −0.47 |
| Ak4 c | 29223 | adenylate kinase 4 | 0.63 |
| Alpl | 25586 | alkaline phosphatase, liver/bone/kidney | 0.53 |
| Amacr | 25284 | alpha-methylacyl-CoA racemase | 0.50 |
| Angpt2 a | 89805 | angiopoietin 2 | −0.79 |
| Anxa2 | 56611 | annexin A2 | −0.45 |
| Apoh d | 287774 | apolipoprotein H (beta-2-glycoprotein I) | −1.52 |
| Aqp2 d | 25386 | aquaporin 2 (collecting duct) | −0.47 |
| Baat | 29725 | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) | 0.78 |
| Car2 | 54231 | carbonic anhydrase 2 | 0.53 |
| Cftr | 24255 | cystic fibrosis transmembrane conductance regulator | −1.22 |
| Cldn19 | 298487 | claudin 19 | −0.53 |
| Clu a,c,d | 24854 | clusterin | −0.80 |
| Col3a1 a,c | 84032 | collagen, type III, alpha 1 | −0.64 |
| Col4a5 | 363457 | collagen, type IV, alpha 5 | −0.45 |
| Comt | 24267 | catechol-O-methyltransferase | −0.67 |
| Csf1r c,d | 307403 | colony stimulating factor 1 receptor | −0.73 |
| Cst3 d | 25307 | cystatin C | −0.50 |
| Cubn d | 80848 | cubilin (intrinsic factor-cobalamin receptor) | 0.68 |
| Cyp1a1 c | 24296 | cytochrome P450, family 1, subfamily a, polypeptide 1 | −0.51 |
| Cyp4a3 | 298423 | cytochrome P450, family 4, subfamily a, polypeptide 3 | 0.52 |
| Dusp1 | 114856 | dual specificity phosphatase 1 | −0.71 |
| Ebag9 | 299864 | estrogen receptor binding site associated, antigen, 9 | 0.49 |
| Ephx2 c,d | 65030 | epoxide hydrolase 2, cytoplasmic | 4.52 |
| F2 c,d | 29251 | coagulation factor II | −0.93 |
| Fbn1 a,d | 83727 | fibrillin 1 | −0.61 |
| Fga c | 361969 | fibrinogen alpha chain | 0.85 |
| Fhit | 60398 | fragile histidine triad | 1.58 |
| Fmod d | 64507 | fibromodulin | −1.09 |
| Fn1 a,c,d | 25661 | fibronectin 1 | −0.98 |
| Gatm c | 81660 | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.86 |
| Gja1 | 24392 | gap junction protein, alpha 1 | 0.99 |
| Gpc1 | 58920 | glypican 1 | −0.72 |
| Gstp1 c | 24426 | glutathione S-transferase pi 1 | 0.53 |
| Gtpbp4 c | 114300 | GTP binding protein 4 | 3.01 |
| Hao1 | 311446 | hydroxyacid oxidase (glycolate oxidase) 1 | −1.60 |
| Hgf d | 24446 | hepatocyte growth factor | −0.77 |
| Igf1 d | 24482 | insulin-like growth factor 1 | −0.75 |
| Igfbp1 d | 25685 | insulin-like growth factor binding protein 1 | 1.26 |
| Il4r | 25084 | interleukin 4 receptor | 0.64 |
| Lama2 | 309368 | laminin, alpha 2 | −0.58 |
| Lgals1 | 56646 | lectin, galactoside-binding, soluble, 1 | 0.88 |
| Lrp1 a | 299858 | low density lipoprotein receptor-related protein 1 | −0.53 |
| Lrp5 | 293649 | low density lipoprotein receptor-related protein 5 | −0.47 |
| Ltbp1 | 59107 | latent transforming growth factor beta binding protein 1 | −0.57 |
| Mif | 81683 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 0.55 |
| Mme | 24590 | membrane metallo-endopeptidase | 1.35 |
| Mmp2 a, c | 81686 | matrix metallopeptidase 2 | −0.54 |
| Mmp9 a, d | 81687 | matrix metallopeptidase 9 | −2.00 |
| Mok | 362787 | MOK protein kinase | −0.93 |
| Mthfr b, c, d | 362657 | methylenetetrahydrofolate reductase (NAD(P)H) | 0.49 |
| Nos3 c, d | 24600 | nitric oxide synthase 3, endothelial cell | −0.55 |
| Nox4 d | 85431 | NADPH oxidase 4 | 0.50 |
| Nphs2 a | 170672 | nephrosis 2, idiopathic, steroid-resistant | 0.57 |
| Pecam1 d | 29583 | platelet/endothelial cell adhesion molecule 1 | −0.45 |
| Pla2g4a | 24653 | phospholipase A2, group IVA (cytosolic, calcium-dependent) | −0.69 |
| Ptgds b, d | 25526 | prostaglandin D2 synthase (brain) | −0.78 |
| Ptk2b | 50646 | protein tyrosine kinase 2 beta | −0.79 |
| Rap1gap a | 313644 | Rap1 GTPase-activating protein | −0.60 |
| Retn c, d | 246250 | resistin | expression was detected only in ISIAH rats |
| RT1-Bb | 309622 | RT1 class II, locus Bb | −1.26 |
| Serpinf1 d | 287526 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | −2.10 |
| Serping1 | 295703 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.56 |
| Sfrp1 | 84402 | secreted frizzled-related protein 1 | −0.61 |
| Slc17a2 | 306950 | solute carrier family 17, member 2 | 0.59 |
| Slc19a3 c | 316559 | solute carrier family 19 (thiamine transporter), member 3 | 1.00 |
| Slc5a2 | 64522 | solute carrier family 5 (sodium/glucose cotransporter), member 2 | 0.64 |
| Slc6a19 | 664630 | solute carrier family 6 (neutral amino acid transporter), member 19 | 0.48 |
| Slit2 | 360272 | slit homolog 2 (Drosophila) | 0.45 |
| Sod3 d | 25352 | superoxide dismutase 3, extracellular | 0.56 |
| Tf d | 24825 | transferrin | −1.43 |
| Timp2 d | 29543 | TIMP metallopeptidase inhibitor 2 | −0.52 |
| Vcam1 c,d | 25361 | vascular cell adhesion molecule 1 | −0.86 |
| Vtn d | 29169 | vitronectin | −1.18 |
Genes associated with: arenal fibrosis; bnephrosclerosis; crenal insufficiency, ddiabetic nephropathy; ISIAH and WAG – rat strains used in the study