Table 1.

Candidate SNP markers of aggressiveness as an adverse effect of medical treatments (these markers may change the TBP–promoter affinity)

Gene	dbSNP [12] or see [Reference]	5′ flank	$\frac{\mathbf{wt}}{mut}$	3′ flank	KD, nM		Z-score		Known diseases (observations) [Reference] or hypothetical ones in the case of the candidate SNP markers predicted by us in [this work] (see Methods: Additional file 2 : Figure S1)	[Ref] or [this work]
					$\frac{\mathbf{wt}}{mut}$	Δ	Z	α
GH1	rs11568827	aggggccagg	$\frac{\mathbf{g}}{-}$	tataaaaagg	$\frac{\mathbf{1.5}}{\mathit{1.4}}$	=	1	-	Short stature (unknown TF-binding site damaged rather than TATA box)	[69]
									(hypothetically) low aggression of patients during growth hormone treatment (case review); short stature and aggressiveness co-exist in Smith-Magenis syndrome, Dubowitz syndrome, Floating-Harbor syndrome; and females with constitutional short stature are more aggressive than the ones with Turner syndrome; children and adolescents with hypopituitarism have short stature and show a tendency to avoid aggressiveness (case reviews)	[this work] [70–75]
	rs796237787	gaaggggcca	$\frac{\mathbf{g}}{-}$	ggtataaaaa	$\frac{\mathbf{1.5}}{\mathit{1.4}}$	=	1	-
	rs768454929	agggtataaa	$\frac{\mathbf{a}}{c}$	agggcccaca	$\frac{\mathbf{1.5}}{\mathit{2.6}}$	↓	7	10−6
	rs761695685	gccagggtat	$\frac{\mathbf{a}}{g}$	aaaagggccc	$\frac{\mathbf{1.5}}{\mathit{5.8}}$	↓	19	10−6
	rs774326004	ccagggtata	$\frac{\mathbf{a}}{t}$	aaagggccca	$\frac{\mathbf{1.5}}{\mathit{0.9}}$	↑	7	10−6	(hypothetically) higher aggression of a mentally unstable patient during growth hormone treatment so that lithium (Li) and other antiaggression medication may be required (a retrospective clinical case review)	[this work] [70]
	rs777003420	aaggggccag	$\frac{\mathbf{g}}{t}$	gtataaaaag	$\frac{\mathbf{1.5}}{\mathit{1.3}}$	↑	3	0.05
IL1B	rs1143627	ttttgaaagc	$\frac{\mathbf{c}}{t}$	ataaaaacag	$\frac{\mathbf{5}}{2}$	↑	15	10−6	Greater body fat; gastric cancer, hepatocellular carcinoma, non-small cell lung cancer, gastritis and gastric ulcer, Graves’ disease, major recurrent depression, and also, (hypothetically) higher aggressiveness in patients who receive cytokine immunotherapy (clinical retrospective review) as well as Graves’ disease and aggressiveness are consequences of regular hemodialysis	[77–83], [this work] [84] [85]
	rs549858786	tgaaagccat	$\frac{\mathbf{a}}{t}$	aaaacagcga	$\frac{\mathbf{5}}{6}$	↓	8	10 −6	(hypothetically) less aggressive traits in patients who receive cytokine immunotherapy or regular hemodialysis (clinical retrospective review)	[this work],[84]

Notes: hereinafter, TBP, TATA-binding protein; TATA-box, the canonical TBP-binding site; wt, ancestral allele; mut, minor allele; K_D, an estimate [52] of the dissociation constant (K_D) of the TBP-DNA complex in vitro [53]; Δ, the expression change in comparison with the norm: overexpression (↑), underexpression (↓), norm (=); Z Z-score; α = 1 – p, significance, where p is probability (Fig. 1); TF, transcription factor; ALS, amyotrophic lateral sclerosis